SIGRIMA™ is administered via IV infusion, delivering the medication directly into the bloodstream through a vein.1
As IV infusions
Once every 3 weeks
For 1 year
(up to 18 cycles)*
SIGRIMA™ and trastuzumab are administered
consecutively during the same visit. Additionally,
chemotherapy may be included in your treatment plan,
potentially following a separate schedule.1
If you begin SIGRIMA + trastuzumab-based therapy
before surgery, you may continue it after the procedure
to complete a duration of 1 year (up to 18 cycles).1,*
*Unless side effects become unmanageable or if cancer recurrence occurs sooner.
Infusion durations may vary based on individual
tolerability.
Following the administration of each medication, your
doctor or nurse will observe for any reactions for 30 to
60 minutes. If a reaction occurs, they may modify,
postpone, or halt the treatment accordingly.1
Although a full course of SIGRIMA™ + trastuzumab-based therapy lasts a year,1 chemotherapy is usually discontinued earlier. Your doctor will determine the appropriate chemotherapy regimen for you.1
SIGRIMA™
infusion
Trastuzumab
infusions
Chemotherapy
infusion
During your initial visit, medications are administered at a slower pace. The first dose of SIGRIMA™ will be infused over 60 minutes, while trastuzumab will be given over 90 minutes.1 Chemotherapy infusion durations may differ depending on the regimen.2
Explore resources and information to facilitate an informed discussion with your doctor.
Talk to your doctor
Diarrhea means you have loose or watery stools 3 or more times a day.4
Tips to manage diarrhea5
Alopecia, or hair loss, can affect any part of the body.3,5
Tips to manage alopecia3,5
Nausea is an unpleasant feeling in your stomach that may come and go in the form of waves. This usually occurs before vomiting, when you may throw up the contents of the stomach through the mouth.7
Tips to manage nausea and vomiting8,9
Fatigue is a sensation of weariness or depletion that can impact your capacity to engage in regular tasks.10,11
Tips to manage fatigue
During treatment, it’s possible to experience constipation and encounter challenges with bowel movements.12
Here are some suggestions you might consider.12
While the severe side effects of SIGRIMA™ are not experienced by everyone, side effects from SIGRIMA™ are common.1 So, it is important for you to know the symptoms and side effects one should look out for.
In case the side effects start becoming more serious, your doctor may stop the treatment. This is why you shouldimportantsafety report the side effects you are worried about to your doctor, and be sure to ask all your queries regarding the treatment.
SIGRIMA™, in some cases, may lead to cardiovascular (heart) problems,which may or may not cause symptoms. For example, congestive heart failure and decreased function of the heart.2,3
Your doctor may test your heart health before treating with SIGRIMA™ and will also monitor your heart function throughout the treatment. Based on the test results, your doctor may stop or pause the treatment with SIGRIMA™.
If you experience any of the following symptoms with SIGRIMA™, seek professional help immediately:
difficulty breathing (new onset or worsening of existing condition), face/ankle/leg swelling, heart palpitations, feeling dizzy, sudden excess weight gain (>2.2 kg) in 1 day, or loss of consciousness.4
It is recommended to use birth control during your treatment with SIGRIMA™, which should be continued for 7 months after your last SIGRIMA™ dose.4
For breastfeeding women, it is important to talk to a doctor regarding the discontinuation of breastfeeding while on SIGRIMA™ or pausing treatment with SIGRIMA™.5
During your course of treatment with SIGRIMA™, if you are worried you might be pregnant, you should seek professional advice immediately.
You should not use SIGRIMA™ if you’re allergic to Pertuzumab or other ingredients found in SIGRIMA™. SIGRIMA™ is delivered via a needle directly into your vein4, which is why it can be linked to infusion-related reactions that may or may not be fatal in nature.7 Commonly observed reactions when receiving SIGRIMA™ + Trastuzumab + docetaxel include 4,8:
Commonly observed reactions when receiving ONLY SIGRIMA™ include,4:
Some people may also experience hypersensitivity reactions or anaphylaxis with SIGRIMA™, which are serious allergic reactions that can sometimes occur suddenly and are capable of affecting different areas of the body. These reactions have been reported to be fatal in some cases.9
The most commonly seen side effects of SIGRIMA™ + Trastuzumab + chemotherapy in those who are being treated for early breast cancer before surgery are4,10:
NOTE: Side effects experienced changes during the chemotherapy regimen.
Commonly seen side effects of SIGRIMA™ when given in combination with Trastuzumab and chemotherapy as part of an early breast cancer regimen post surgery are4,11:
Commonly seen side effects of SIGRIMA™ when given in combination with Trastuzumab and docetaxel for treatment of metastatic breast cancer (that has spread to different parts of the body) are4,8,12:
It is advised that you report any side effects to Zydus pharmacovigilance cell (Contact center: 1800 419 1141 / Email: drugsafety@zyduslife.com). You should speak to your healthcare professional to learn more about the benefits and risks associated with the use of SIGRIMA™. It is also advised that you check out the entire prescribing information of the medicine for additional safety information and other possible side effects.
SIGRIMA™ (Pertuzumab) is a medicine prescribed by healthcare professionals in combination with Trastuzumab and chemotherapy13 in the following cases:
SIGRIMA™ (Pertuzumab) is a medicine prescribed by healthcare professionals and has been approved for treatment of people who have HER2+ metastatic breast cancer (that has spread to other parts of the body)10 and also who have not received anti-HER2 therapy or chemotherapy for metastatic breast cancer, in combination with Trastuzumab and docetaxel.4